Pleiotropic effect of statins

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August undefined, 2024

WebbIn RA patients, the risk of CVD is reduced by statin treatment, and statin discontinuation is associated with an increased cardiovascular disease risk. Summary: The combined effect of statins on improving vascular function, lowering lipid levels, and reducing inflammation in RA patients is responsible for the decreased all-cause mortality in ... WebbThe pleiotropic benefits of statins may result from their impact on vascular inflammation. The molecular process underlying this phenomenon is not fully elucidated. Here, RNA …

Pleiotropic Effects of Statins-What is their Clinical Significance?

WebbRecent experimental and clinical evidence suggests that the beneficial effects of statins may extend beyond their cholesterol-lowering effects, to include so-called pleiotropic … WebbPleiotropic effects of statins Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are beneficial in the primary and secondary prevention of coronary … maywood proviso rotary club

Pleiotropic Effects of Statins on the Cardiovascular System

WebbIndeed, recent studies indicate that some of the cholesterol-independent or “pleiotropic” effects of statins involve improving endothelial function, enhancing the stability of … WebbDespite the progressions in COVID-19 understanding, the optimization of patient-specific therapies remains a challenge. Statins, the most widely prescribed lipid-lowering drugs, received considerable attention due to their pleiotropic effects, encompassing lipid metabolism control and immunomodulatory and anti-thrombotic effects. In COVID-19 … Webb1 dec. 2024 · A summary of pleiotropic effects of statins in different diseases. HMG-CoA reductase is responsible for the conversion of HMG-CoA to MA, which is a crucial intermediate molecule in the production of cholesterol and a wide range of non-steroidal isoprenoid intermediates, including GGPP, FPP, and IPP ( Fig. 1) [ 35 ]. maywood property maintenance violations

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Isoprenoid Metabolism and the Pleiotropic Effects of Statins

Webb6 jan. 2024 · Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate. Regulatory agencies require that new cholesterol-lowering … WebbPleiotropic effects of statins in atrial fibrillation patients: the evidence Hadi AR Hadi, Wael Al Mahmeed, Jassim Al Suwaidi, Samer EllahhamInstitute of Cardiac Sciences, Sheikh Khalifa Medical City, Abu Dhabi, United Arab EmiratesAbstract: Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. The understanding of the … maywood property groupWebbPleiotropic effects of statins Indian J Endocrinol Metab. Sep-Oct 2015;19 (5):554-62. doi: 10.4103/2230-8210.163106. Authors Narasaraju Kavalipati 1 , Jay Shah 2 , Ananthraman … maywood proviso state bank

"Webb1 sep. 2016 · In addition, statins have been shown to exert extrahepatic, cholesterol independent effects in animal studies that have been referred to as pleiotropic effects that include direct effects on vascular tissue, heart, kidney, bone, and glucose metabolism that are apparently independent of their action on blood lipids ( Palinski, 2001, Ferro, 2002 ... " - Pleiotropic effect of statins

Pleiotropic effect of statins

Pleiotropic and Adverse Effects of Statins-Do Epigenetics Play

Webb17 sep. 2015 · “Pleiotropic" effects of statins involve improving endothelial function, decreasing vascular inflammation and oxidative stress, and inhibiting the thrombogenic … Webb1 okt. 2015 · Metaanalysis of 92 placebo-controlled and active-comparator trials demonstrated that statins are effective for primary and secondary cardiovascular prevention, reducing major coronary events and...

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WebbSteroid drugs, such as prednisone and prednisolone, have pleiotropic effects, including systemic ones, for the same reason that endogenous steroid hormones do too: cells throughout the body have receptors that can respond to them, because the endogenous ones are endocrine messengers. See also. Adverse effect; Pleiotropy in genetics; …

Webb1 apr. 2002 · In summary, accumulating evidence from basic research and clinical trials indicates that statins have pleiotropic effects that may largely account for the clinical … Webb1 nov. 2005 · This review summarizes the new findings in these pleiotropic effects of 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and describes their impact on vascular processes. Purpose of review 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are the most widely prescribed drugs worldwide for lowering …

Webb5 jan. 2012 · Pleiotropic effects may be undesirable (such as side effects or toxicity), neutral, or, as is especially the case with HMG-CoA reductase inhibitors (statins), … Webbtial pleiotropic effect of simvastatin or other statins remains uncertain. The chosen combination is recom-mended for clinical practice which is an important reason to study its impact on vascular function. Fur-thermore, if pleiotropic effects are important, one would have expected some indication of a dose rela-

WebbThe Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia. Statins, 3-hydroxy-methylglutaryl coenzyme …

Webb1 dec. 2024 · Statins exhibit "pleiotropic" properties that are independent of their lipid-lowering effects. For example, preclinical evidence suggests that statins inhibit tumor … maywood property taxesWebbIn the scope of review, we highlight statins and their pleiotropic effects with reference to their harmful and beneficial effects as a novel approach for their use in the treatment of … maywood propertyWebbPleiotropic effects may be undesirable (such as side effects or toxicity), neutral, or, as is especially the case with HMG-CoA reductase inhibitors (statins), beneficial. Pleiotropic … maywood public defenderWebbStatins also have a wide range of beneficial biological effects in addition to lipid lowering, a phenomenon commonly termed a ‘pleiotropic effect’ (3–6). These effects include anti … maywood psychiatric hospitalWebb7 apr. 2024 · Request PDF The pleiotropic effects of statins in rheumatoid arthritis Objectives: Rheumatoid arthritis (RA) is an inflammatory and autoimmune disease. … maywood public library ilWebb15 juni 2007 · Current debate centers on whether the pleiotropic effects of statins are really due to other properties that the drugs possess, ... For example, the ENCORE I (Evaluation of Nifedipine and Cerivastatin Function) trial, which assesses the effect of statin therapy on endothelial function, is in progress. maywood public library addressWebbThe pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis. Statins have been demonstrated to … maywood public library