Phosphopantetheine-binding protein

WebOct 5, 2001 · 4'-Phosphopantetheine transferases (PPTases) transfer the 4'-phosphopantetheine moiety of coenzyme A onto a conserved serine residue of acyl … WebFeb 1, 2024 · The reaction mechanism of PPAT involves a nucleophilic attack by 4′-phosphate of phosphopantetheine on the α-phosphate of ATP in an in-line displacement …

Structure, function and dynamics in acyl carrier proteins

WebJun 3, 2010 · Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis in complex with 4'-phosphopantetheine. ... Find proteins for P9WPA5 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)) Explore P9WPA5 . Go to UniProtKB: P9WPA5. Entity Groups Sequence Clusters: WebUsing Escherichia coli LipB as a model enzyme, we show here that the octanoyl-transferase mainly recognizes the 4'-phosphopantetheine-tethered acyl-chain of its donor substrate … eastland women\u0027s newbury penny loafer https://bbmjackson.org

Phosphopantetheine Adenylyltransferase: A promising drug target …

WebProteomics of Streptococcus mutans to Reveal the Antibiofilm Formation Mechanism of Ag/ZnO Nanocomposites with Light-Emitting Diode Radiation WebSep 29, 2024 · A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and … WebPhosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) catalyzes an essential step in the reaction that transfers an adenylyl group from adenosine tri phosphate (ATP) to 4' … eastland women\u0027s penny loafers back in style

US20050107308A1 Dipeptidyl peptidase IV inhibitors and their …

Category:Extracellular 4′-phosphopantetheine is a source for intracellular ...

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Phosphopantetheine-binding protein

BGC0000314 - secondarymetabolites.org

WebJul 10, 2024 · ACP3 is a four-helix bundle with S38 being unmodified in the apo form of the protein, phosphopantheine bound in the holo form, and with polyketide substrate attached … WebNov 4, 2024 · tyrosine-protein kinase is fine as a protein name but capsular polysaccharide biosynthesis would be more appropriate as a function. RimM protein, required for 16S …

Phosphopantetheine-binding protein

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WebJul 21, 2024 · The phosphopantetheine-binding domain (PP-binding superfamily), conserved in ACP proteins, is the prosthetic group of ACP, which acts as a linker for the attachment of the activated FA and amino acid groups via a phosphodiester bond ( Crawford et al. 2008; Meier et al. 2010; Roujeinikova et al. 2002 ). WebPhosphopantetheine-binding protein (Pectobacterium carotovorum PC1) - STRING interaction network Nodes: Network nodes represent proteins splice isoforms or post …

WebJul 1, 2003 · Phosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer of an adenylyl group from Mg2+:ATP to 4′-phosphopantetheine to form 3′-dephospho-CoA (dPCoA) and pyrophosphate. WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. …

WebJan 8, 2024 · 4'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function 4'-Phosphopantetheine and long acyl … WebThe mitochondrial acyl carrier protein (human ACPM, yeast Acp1) is an essential mitochondrial protein. Through binding of nascent acyl chains on the serine (S112)-bound …

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WebAlthough holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al.in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superfamily. eastland women\u0027s classic ii penny loaferWebIts deduced protein was most related to mouse U26. Thus, we termed it human U26. This putative protein contains an AMP-binding domain, a Phosphopantetheine-binding … cultural characteristics of ancient persiaWebMar 3, 2006 · In most bacteria, the so-called Dfp proteins catalyze the synthesis of the coenzyme A precursor 4′-phosphopantetheine. Dfp proteins are bifunctional enzymes catalyzing the synthesis of 4′-phosphopantothenoylcysteine (CoaB activity) and its decarboxylation to 4′-phosphopantetheine (CoaC activity). ... (maltose-binding protein) … eastland women\u0027s holly penny loaferWebprotein Summary Phosphopantetheine-binding protein (Streptomyces rimosus subsp. rimosus ATCC 10970) Cite Download Contents 1 Sequence 2 Interactions and Pathways 3 … eastland women\u0027s yarmouth suede boat shoesWebJan 3, 2024 · Using E. coli LipB as a prototype, we show that the enzyme mainly recognizes the 4’-phosphopantetheine tethered acyl-chain of its donor substrate, and weakly binds the apo-acyl carrier protein. It can accept octanoate-from its own ACP, noncognate ACPs, as well as C 8 -CoA. eastland women\u0027s shoes on saleWebJan 18, 1999 · Each phosphopantetheine adenylyltransferase (PPAT) subunit displays a dinucleotide-binding fold that is structurally similar to that in class I aminoacyl-tRNA synthetases. Superposition of bound adenylyl moieties from dPCoA in PPAT and ATP in aminoacyl-tRNA synthetases suggests nucleophilic attack by the 4'-phosphopantetheine … cultural characteristics of baby boomersWebphosphopantetheine-binding protein 61012291 - Gene ResultWI98_RS26710 phosphopantetheine-binding protein [] Gene provides a unified query environment for … eastland women\u0027s sandals