Cisplatin and sodium thiosulfate

Author: ugdv

August undefined, 2024

WebApr 9, 2024 · The FDA previously approved sodium thiosulfate injection in September 2024 to decrease the risk of cisplatin-associated hearing loss in pediatric patients. 2 Data from the SIOPEL6 trial and COG ACCL0431 study supported the FDA’s decision to … WebCisplatin-induced ototoxicity is caused by irreversible damage to hair cells in the cochlea hypothesized to be due to a combination of reactive oxygen species production and direct alkylation of DNA leading to cell death. Sodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species. Regulatory Status

Sodium Thiosulfate for Protection from Cisplatin-Induced …

WebSodium thiosulfate is a neutralizing agent for cisplatin that protects against renal damage. To determine whether injection of thiosulfate would permit larger doses of cisplatin to … WebSep 22, 2024 · Sodium thiosulfate is administered as an IV infusion over 15 minutes following cisplatin infusions of 1–6 hours. View the full prescribing information for … option word 2016

Interaction of cisplatin and carboplatin with sodium thiosulfate ...

WebSep 21, 2024 · About PEDMARK® (sodium thiosulfate injection) PEDMARK ® is the first and only U.S. Food and Drug Administration (FDA) approved therapy indicated to reduce … WebSep 22, 2024 · On September 20, 2024, the U.S. Food and Drug Administration (FDA) approved the use of sodium thiosulfate (Pedmark®) to reduce the risk of ototoxicity associated with cisplatin in pediatric patients aged 1 month and older with localized, nonmetastatic solid tumors. WebApr 7, 2024 · The active substance of Pedmarqsi is sodium thiosulfate (ATC code not yet assigned), an antidote with a mechanism of action that is not fully understood but is thought to include increasing levels of endogenous antioxidants, inhibition of intracellular oxidative stress and direct interaction with cisplatin to prevent cisplatin-induced damage to … portlys father in the wind in the willows

Interaction of cisplatin and carboplatin with sodium thiosulfate ...

Webcompared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects … WebSomani et al. 1995), sodium thiosulfate (Markman et al. 1991), S-2-(3-aminopropylamino)-ethyl phosphorothioic acid (WR2721) (Yuhas & Culo 1980), glutathione (GSH, ... cisplatin was given as intraperitoneal infusion (16 ml/kg) over a 30 min. period through syringe pump using butterﬂy needle 23À3/4 portly wool coatsWebJul 6, 2024 · Now, results of the randomized, phase III SIOPEL 6 trial demonstrate that sodium thiosulfate (STS) has considerable efficacy in preventing cisplatin-induced … option worksheet

"WebApr 7, 2024 · On 30 March 2024, the European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending … " - Cisplatin and sodium thiosulfate

Cisplatin and sodium thiosulfate

WebFeb 14, 2024 · Sodium thiosulfate injection was approved by the FDA in September 2024 to help decrease the risk of hearing loss in patients 1 month or older with localized, non-metastatic solid tumors who will receive treatment with cisplatin. 2 The injection was evaluated in 2 clinical trials: the phase 3 SIOPEL6 trial (NCT00652132) in a pediatric … WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated.

Did you know?

WebToxicity of cisplatin can be decreased by concomitant administration of sodium thiosulfate, which perhaps chemically inactivates this platinum compound. We studied … WebApr 14, 2024 · Clinically, sodium thiosulfate (STS) is an approved drug for the treatment of acute cyanide and cisplatin toxicity. IR protective abilities of STS are reported with in …

WebFeb 17, 2024 · Cisplatin extravasation, concentrated: Infants, Children, and Adolescents: Inject 2 mL of a 1/6 M (~4%) sodium thiosulfate solution into existing IV line for each 100 mg of cisplatin extravasated; consider also injecting 1 mL of a 1/6 M (~4%) sodium thiosulfate solution as 0.1 mL subcutaneous injections (clockwise) into the area around … WebApr 25, 2024 · Drug: Cisplatin Drug: Sodium thiosulfate Procedure: Cytoreductive surgery: Phase 2: Detailed Description: Adrenocortical carcinoma (ACC) is a rare tumor with an overall 5-year mortality rate of 75 - 90% and an average survival from the time of diagnosis of 14.5 months. The treatment of choice for a localized primary or recurrent …

WebOct 6, 2024 · Sodium thiosulfate prevents hearing loss and is safe. Cisplatin belongs to a group of platinum-based chemotherapy drugs. Research has suggested that hearing … WebMar 29, 2024 · An important step forward in addressing this was the recent approval of intravenous sodium thiosulfate by the US Food and Drug Administration to treat ototoxicity in pediatric patients with localized, nonmetastatic solid tumors. 11 However, for adult patients, there are no currently approved therapies for cisplatin-induced ototoxicity. Until ...

WebNov 22, 2024 · The drugs sodium thiosulfate and mannitol may protect against cisplatin-induced hearing loss. Specifically, sodium thiosulfate has been found to protect the cells in the inner ear, and may therefore prevent hearing loss. Mannitol can help sodium thiosulfate enter the inner ear, and ponteially increase the effectiveness of sodium …

WebJun 21, 2024 · The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among … portly\\u0027s father wind in the willowsWebApr 14, 2024 · Clinically, sodium thiosulfate (STS) is an approved drug for the treatment of acute cyanide and cisplatin toxicity. IR protective abilities of STS are reported with in-vivo models of myocardial IR as both preconditioning and post conditioning agent (Ravindran and Kurian 2024a ). portlynthWebDosing per FDA Guidelines. The recommended dose of sodium thiosulfate (e.g., Pedmark) is based on body surface area according to actual body weight as summarized below … option x18 – limitation of liabilityWebFeb 1, 2024 · This medicine is given 6 hours after receiving cancer medicine (eg, cisplatin). You may also receive other medicine (eg, allergy medicine, steroid medicine) or … option writerWebToxicity of cisplatin can be decreased by concomitant administration of sodium thiosulfate, which perhaps chemically inactivates this platinum compound. We studied the disappearance of cisplatin and carboplatin in aqueous solutions of thiosulfate at 37 degrees C by means of liquid chromatography. option x5WebFeb 14, 2024 · FDA approves sodium thiosulfate to reduce the risk of ototoxicity associated with cisplatin in pediatric patients with localized, non-metastatic solid tumors. … portm smile photoshoot portlys father